Interleukin-10 (IL-10): an update on its relevance for cardiovascular risk
نویسندگان
چکیده
منابع مشابه
Interleukin-10 (IL-10): an update on its relevance for cardiovascular risk.
Inflammation plays a major role in the pathogenesis of atherosclerotic lesions of vascular walls. This concept, initially promoted by Ross [1], was confirmed by several lines of evidence in recent years. Components of the inflammatory system were found in the atheromatous plaque, a relation between lipid metabolism, endothelial damage and inflammation was pointed out, and progression or instabi...
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UNLABELLED The human cytomegalovirus (HCMV) gene UL111A encodes cytomegalovirus-encoded human interleukin-10 (cmvIL-10), a homolog of the potent immunomodulatory cytokine human interleukin 10 (hIL-10). This viral homolog exhibits a range of immunomodulatory functions, including suppression of proinflammatory cytokine production and dendritic cell (DC) maturation, as well as inhibition of major ...
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Interleukin-10 (IL-10) is thought to promote intracellular infection, including human visceral leishmaniasis, by disabling Th1 cell-type responses and/or deactivating parasitized tissue macrophages. To develop a rationale for IL-10 inhibition as treatment in visceral infection, Th1 cytokine-driven responses were characterized in Leishmania donovani-infected BALB/c mice in which IL-10 was absent...
متن کاملInterleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes
In the present study we demonstrate that human monocytes activated by lipopolysaccharides (LPS) were able to produce high levels of interleukin 10 (IL-10), previously designated cytokine synthesis inhibitory factor (CSIF), in a dose dependent fashion. IL-10 was detectable 7 h after activation of the monocytes and maximal levels of IL-10 production were observed after 24-48 h. These kinetics ind...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2003
ISSN: 1460-2385
DOI: 10.1093/ndt/gfg311